frequencies of clinically important single nucleotide polymorphisms of cytochrome p450 cyp1a2 in healthy iranian population using taqman genotyping assay

allele frequencies of single nucleotide polymorphisms of cytochrome p450 cyp2c8 in an iranian population using taqman genotyping assay

allele and genotype frequencies of single nucleotide polymorphisms of cytochrome p450 cyp2c19 in an iranian population using taqman genotyping assay

frequency of single nucleotide polymorphisms of cytochrome p450 cyp2c9 in an iranian population using taqman genotyping assay

rapid single-nucleotide polymorphism detection of vitamin k epoxide reductase (vkorc1) genes in an iranian population using taqman genotyping assay

Association between Cytochrome P450 2C19 Gene Polymorphisms and Hematological Malignancies in an Iranian Population

Background: Cytochrome P450 2C19 (CYP2C19) is widely involved in the metabolism of some medications. On the other hand, recent studies have shown the contribution of the CYP2C19 polymorphisms to different malignancies. We aimed to investigate the association between CYP2C19 polymorphism and occurrence of hematological malignancies by comparing the phenotype distribution of this enzyme in patien...

Multiplex genotyping of cytochrome p450 single-nucleotide polymorphisms by use of MALDI-TOF mass spectrometry.

BACKGROUND Polymorphisms in cytochrome P450 (CYP450) genes contribute to interindividual differences in the metabolism of xenobiotic chemicals, including the vast majority of drugs, and may lead to toxicity and adverse drug reactions. Studies on these polymorphisms in research and diagnostic settings typically involve large-scale genotyping and hence require high-throughput assays. METHODS We...